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CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks.
Cofsky, Joshua C; Karandur, Deepti; Huang, Carolyn J; Witte, Isaac P; Kuriyan, John; Doudna, Jennifer A.
Affiliation
  • Cofsky JC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
  • Karandur D; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
  • Huang CJ; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.
  • Witte IP; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.
  • Kuriyan J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
  • Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Elife ; 92020 06 10.
Article in En | MEDLINE | ID: mdl-32519675
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Endodeoxyribonucleases / DNA Breaks, Double-Stranded / CRISPR-Associated Proteins / CRISPR-Cas Systems / Gene Editing / R-Loop Structures Language: En Journal: Elife Year: 2020 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Endodeoxyribonucleases / DNA Breaks, Double-Stranded / CRISPR-Associated Proteins / CRISPR-Cas Systems / Gene Editing / R-Loop Structures Language: En Journal: Elife Year: 2020 Type: Article Affiliation country: United States