A mutation that blocks integrin &#945;<sub>4</sub>ß<sub>7</sub> activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis.

Zhang, Hailong; Zheng, Yajuan; Pan, Youdong; Lin, Changdong; Wang, Shihui; Yan, Zhanjun; Lu, Ling; Ge, Gaoxiang; Li, Jinsong; Zeng, Yi Arial; Chen, Jianfeng

A mutation that blocks integrin α₄ß₇ activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis.

Zhang, Hailong; Zheng, Yajuan; Pan, Youdong; Lin, Changdong; Wang, Shihui; Yan, Zhanjun; Lu, Ling; Ge, Gaoxiang; Li, Jinsong; Zeng, Yi Arial; Chen, Jianfeng.

Affiliation

Zhang H; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Zheng Y; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China. yjzheng@sibcb.ac.cn.
Pan Y; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Lin C; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Wang S; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Yan Z; Department of Orthopedics, the First People's Hospital of Wujiang District, 169 GongYuan Road, Suzhou, 215200, China.
Lu L; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Ge G; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Li J; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.
Zeng YA; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.
Chen J; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.

BMC Biol ; 18(1): 64, 2020 06 10.

Article in En | MEDLINE | ID: mdl-32522281

Subject(s)

Adaptive Immunity; Colitis/genetics; Integrins/genetics; Mutation; Animals; Colitis/immunology; Female; Integrins/metabolism; Male; Mice; Mice, Transgenic

Key words

Activation; Inflammatory bowel disease; Integrin α4ß7; Lymphocyte

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Integrins / Colitis / Adaptive Immunity / Mutation Limits: Animals Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: China

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