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A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Hildebrand, Joanne M; Kauppi, Maria; Majewski, Ian J; Liu, Zikou; Cox, Allison J; Miyake, Sanae; Petrie, Emma J; Silk, Michael A; Li, Zhixiu; Tanzer, Maria C; Brumatti, Gabriela; Young, Samuel N; Hall, Cathrine; Garnish, Sarah E; Corbin, Jason; Stutz, Michael D; Di Rago, Ladina; Gangatirkar, Pradnya; Josefsson, Emma C; Rigbye, Kristin; Anderton, Holly; Rickard, James A; Tripaydonis, Anne; Sheridan, Julie; Scerri, Thomas S; Jackson, Victoria E; Czabotar, Peter E; Zhang, Jian-Guo; Varghese, Leila; Allison, Cody C; Pellegrini, Marc; Tannahill, Gillian M; Hatchell, Esme C; Willson, Tracy A; Stockwell, Dina; de Graaf, Carolyn A; Collinge, Janelle; Hilton, Adrienne; Silke, Natasha; Spall, Sukhdeep K; Chau, Diep; Athanasopoulos, Vicki; Metcalf, Donald; Laxer, Ronald M; Bassuk, Alexander G; Darbro, Benjamin W; Fiatarone Singh, Maria A; Vlahovich, Nicole; Hughes, David; Kozlovskaia, Maria.
Affiliation
  • Hildebrand JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. jhildebrand@wehi.edu.au.
  • Kauppi M; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. jhildebrand@wehi.edu.au.
  • Majewski IJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Liu Z; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Cox AJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Miyake S; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Petrie EJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Silk MA; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Li Z; Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
  • Tanzer MC; Department of Biochemistry, Toho University School of Medicine, Ota-ku, Tokyo, 143-8540, Japan.
  • Brumatti G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Young SN; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Hall C; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3052, Australia.
  • Garnish SE; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Corbin J; Translational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia.
  • Stutz MD; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Di Rago L; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Gangatirkar P; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany.
  • Josefsson EC; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Rigbye K; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Anderton H; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Rickard JA; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Tripaydonis A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Sheridan J; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Scerri TS; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Jackson VE; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Czabotar PE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Zhang JG; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Varghese L; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Allison CC; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Pellegrini M; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, 97006, USA.
  • Tannahill GM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Hatchell EC; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Willson TA; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Stockwell D; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • de Graaf CA; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Collinge J; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Hilton A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Silke N; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Spall SK; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Parkville, VIC, 3052, Australia.
  • Chau D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Athanasopoulos V; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Metcalf D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Laxer RM; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Bassuk AG; The Royal Melbourne Hospital, Melbourne, VIC, 3050, Australia.
  • Darbro BW; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Fiatarone Singh MA; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
  • Vlahovich N; The Royal Melbourne Hospital, Melbourne, VIC, 3050, Australia.
  • Hughes D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Kozlovskaia M; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
Nat Commun ; 11(1): 3150, 2020 06 19.
Article in En | MEDLINE | ID: mdl-32561755
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Hematopoietic Stem Cells / Necroptosis / Hematopoietic System Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Type: Article Affiliation country: Australia
Fulltext
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Hematopoietic Stem Cells / Necroptosis / Hematopoietic System Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Type: Article Affiliation country: Australia