1-Formyl-7-hydroxy-6,7-dihydro-5<i>H</i>-pyrrolizine (1-CHO-DHP)-Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA.

He, Xiaobo; Xia, Qingsu; Zhao, Yuewei; Fu, Peter P

1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP)-Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA.

He, Xiaobo; Xia, Qingsu; Zhao, Yuewei; Fu, Peter P.

Affiliation

He X; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States.
Xia Q; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States.
Zhao Y; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States.
Fu PP; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States.

Chem Res Toxicol ; 33(8): 2139-2146, 2020 08 17.

Article in En | MEDLINE | ID: mdl-32588618

Subject(s)

Cysteine/metabolism; DNA/metabolism; Hepatocytes/metabolism; Pyrrolizidine Alkaloids/metabolism; Animals; Binding Sites; Cysteine/chemistry; DNA/chemistry; Hep G2 Cells; Hepatocytes/chemistry; Humans; Male; Molecular Structure; Pyrrolizidine Alkaloids/chemistry; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolizidine Alkaloids / DNA / Hepatocytes / Cysteine Limits: Animals / Humans / Male Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: United States

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