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Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Thomas, Sherine E; Whitehouse, Andrew J; Brown, Karen; Burbaud, Sophie; Belardinelli, Juan M; Sangen, Jasper; Lahiri, Ramanuj; Libardo, Mark Daben J; Gupta, Pooja; Malhotra, Sony; Boshoff, Helena I M; Jackson, Mary; Abell, Chris; Coyne, Anthony G; Blundell, Tom L; Floto, Rodrigo Andres; Mendes, Vítor.
Affiliation
  • Thomas SE; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
  • Whitehouse AJ; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  • Brown K; University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Burbaud S; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB2 0AY, UK.
  • Belardinelli JM; University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Sangen J; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Lahiri R; University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Libardo MDJ; National Hansen's Disease Program, Healthcare Systems Bureau, Health Resources and Services Administration, Department of Health and Human Services, Baton Rouge, LA, USA.
  • Gupta P; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  • Malhotra S; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
  • Boshoff HIM; Birkbeck College, University of London, Malet Street WC1E7HX, UK.
  • Jackson M; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  • Abell C; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Coyne AG; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  • Blundell TL; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
  • Floto RA; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
  • Mendes V; University of Cambridge Molecular Immunity Unit, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Nucleic Acids Res ; 48(14): 8099-8112, 2020 08 20.
Article in En | MEDLINE | ID: mdl-32602532
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: TRNA Methyltransferases / Bacterial Proteins / RNA, Transfer / Enzyme Inhibitors / Anti-Bacterial Agents Language: En Journal: Nucleic Acids Res Year: 2020 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: TRNA Methyltransferases / Bacterial Proteins / RNA, Transfer / Enzyme Inhibitors / Anti-Bacterial Agents Language: En Journal: Nucleic Acids Res Year: 2020 Type: Article Affiliation country: United kingdom