Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis.

Ni, Huaner; Xu, Shuang; Chen, Hangwei; Dai, Qiuyan

Ni, Huaner; Xu, Shuang; Chen, Hangwei; Dai, Qiuyan.

Affiliation

Ni H; From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.
Xu S; From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.
Chen H; From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.
Dai Q; From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.

Arterioscler Thromb Vasc Biol ; 40(9): 2054-2069, 2020 09.

Article in En | MEDLINE | ID: mdl-32640907

Subject(s)

Atherosclerosis/drug therapy; Autophagy/drug effects; Cathepsins/biosynthesis; Lysosomes/drug effects; Muscle, Smooth, Vascular/drug effects; Myocytes, Smooth Muscle/drug effects; Nicotine/pharmacology; Animals; Atherosclerosis/enzymology; Atherosclerosis/genetics; Atherosclerosis/pathology; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism; Cathepsins/genetics; Cell Line; Cell Movement/drug effects; Disease Models, Animal; Exocytosis; Lysosomes/enzymology; Lysosomes/ultrastructure; Mechanistic Target of Rapamycin Complex 1/metabolism; Mice, Knockout, ApoE; Muscle, Smooth, Vascular/enzymology; Muscle, Smooth, Vascular/ultrastructure; Myocytes, Smooth Muscle/enzymology; Myocytes, Smooth Muscle/ultrastructure; Secretory Pathway; Signal Transduction; rab GTP-Binding Proteins/genetics; rab GTP-Binding Proteins/metabolism

Key words

atherosclerosis; autophagy; cathepsin S; lysosome; nicotine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Cathepsins / Myocytes, Smooth Muscle / Atherosclerosis / Lysosomes / Muscle, Smooth, Vascular / Nicotine Type of study: Prognostic_studies Limits: Animals Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2020 Type: Article Affiliation country: China

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