Micelle Driven Oxidation Mechansim and Novel Oxidation Markers for Different Grades of Polysorbate 20 and 80.

Kranz, Wendelin; Wuchner, Klaus; Corradini, Eleonora; Menzen, Tim; Hawe, Andrea

Kranz, Wendelin; Wuchner, Klaus; Corradini, Eleonora; Menzen, Tim; Hawe, Andrea.

Affiliation

Kranz W; Coriolis Pharma Research, Fraunhoferstr. 18 b, 82152 Martinsried, Germany.
Wuchner K; Janssen Research and Development, DPD&S BioTherapeutics Development, Hochstrasse 201, 8205 Schaffhausen, Switzerland.
Corradini E; Coriolis Pharma Research, Fraunhoferstr. 18 b, 82152 Martinsried, Germany.
Menzen T; Coriolis Pharma Research, Fraunhoferstr. 18 b, 82152 Martinsried, Germany.
Hawe A; Coriolis Pharma Research, Fraunhoferstr. 18 b, 82152 Martinsried, Germany. Electronic address: Andrea.Hawe@coriolis-pharma.com.

J Pharm Sci ; 109(10): 3064-3077, 2020 10.

Article in En | MEDLINE | ID: mdl-32653599

Subject(s)

Micelles; Polysorbates; Hydrolysis; Mass Spectrometry; Oxidation-Reduction

Key words

Analytical chemistry; Degradation product(s); Excipient(s); Injectable(s); Liquid chromatography coupled to mass spectrometry (LC-MS); Micelle chemistry; Oxidation marker(s); Oxidation(s); Protein formulation(s); Surfactant(s)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysorbates / Micelles Language: En Journal: J Pharm Sci Year: 2020 Type: Article Affiliation country: Germany

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