Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma.

Mohammad, Mohammad Abdul-Azim; Mahrouse, Marianne Alphonse; Amer, Enas Abdel Hakeem; Elharati, Nouran Saleh

Mohammad, Mohammad Abdul-Azim; Mahrouse, Marianne Alphonse; Amer, Enas Abdel Hakeem; Elharati, Nouran Saleh.

Affiliation

Mohammad MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mahrouse MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Amer EAH; National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
Elharati NS; National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Biomed Chromatogr ; 34(12): e4955, 2020 Dec.

Article in En | MEDLINE | ID: mdl-32706446

Subject(s)

Chromatography, Liquid/methods; Enalapril/blood; Hydrochlorothiazide/blood; Nitrendipine/blood; Tandem Mass Spectrometry/methods; Drug Stability; Enalapril/chemistry; Enalapril/pharmacokinetics; Humans; Hydrochlorothiazide/chemistry; Hydrochlorothiazide/pharmacokinetics; Linear Models; Nitrendipine/chemistry; Nitrendipine/pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

Key words

LC-MS/MS; enalapril maleate; enalaprilat; hydrochlorothiazide; nitrendipine; validation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enalapril / Nitrendipine / Chromatography, Liquid / Tandem Mass Spectrometry / Hydrochlorothiazide Type of study: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biomed Chromatogr Year: 2020 Type: Article Affiliation country: Egypt

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