Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression.

Srivastava, Ipsit; Vazquez-Juarez, Erika; Henning, Lukas; Gómez-Galán, Marta; Lindskog, Maria

Srivastava, Ipsit; Vazquez-Juarez, Erika; Henning, Lukas; Gómez-Galán, Marta; Lindskog, Maria.

Affiliation

Srivastava I; Dep. Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Vazquez-Juarez E; Dep. Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Henning L; Dep. Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Gómez-Galán M; Dep. Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Lindskog M; Dep. Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.

Cells ; 9(7)2020 07 16.

Article in En | MEDLINE | ID: mdl-32708718

Subject(s)

Astrocytes/metabolism; Depression/physiopathology; Neuronal Plasticity; Prefrontal Cortex/physiopathology; gamma-Aminobutyric Acid/metabolism; Animals; Astrocytes/drug effects; Atrophy; Disease Models, Animal; Long-Term Potentiation/drug effects; Male; Neuronal Plasticity/drug effects; Rats, Sprague-Dawley; Receptors, GABA/metabolism; Selegiline/pharmacology

Key words

Deprenyl; FSL; LTP; MAO-B; MDD; astrocyte; excitation; inhibition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Prefrontal Cortex / Depression / Gamma-Aminobutyric Acid / Neuronal Plasticity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cells Year: 2020 Type: Article Affiliation country: Sweden

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