In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs.

Ding, Sha; Fike, Katherine R; Klemba, Michael; Carlier, Paul R

Ding, Sha; Fike, Katherine R; Klemba, Michael; Carlier, Paul R.

Affiliation

Ding S; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States.
Fike KR; Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States.
Klemba M; Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States.
Carlier PR; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: pcarlier@vt.edu.

Bioorg Med Chem Lett ; 30(17): 127348, 2020 09 01.

Article in En | MEDLINE | ID: mdl-32738996

Subject(s)

Antimalarials/pharmacology; Mannich Bases/chemistry; Plasmodium falciparum/drug effects; Animals; Antimalarials/chemistry; Antimalarials/therapeutic use; Disease Models, Animal; Malaria/drug therapy; Malaria/parasitology; Mannich Bases/pharmacology; Mannich Bases/therapeutic use; Mice; Plasmodium berghei/pathogenicity

Key words

Malaria; Malaria box; PAINs; Parasite; Phenolic mannich base

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Mannich Bases / Antimalarials Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: United States

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