Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.

Haque, Effi; Karim, M Rezaul; Salam Teeli, Aamir; Smiech, Magdalena; Leszczynski, Pawel; Winiarczyk, Dawid; Parvanov, Emil D; Atanasov, Atanas G; Taniguchi, Hiroaki

Haque, Effi; Karim, M Rezaul; Salam Teeli, Aamir; Smiech, Magdalena; Leszczynski, Pawel; Winiarczyk, Dawid; Parvanov, Emil D; Atanasov, Atanas G; Taniguchi, Hiroaki.

Affiliation

Haque E; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Karim MR; Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Salam Teeli A; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Smiech M; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Leszczynski P; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Winiarczyk D; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Parvanov ED; Division BIOCEV, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 420 Prague, Czech Republic.
Atanasov AG; Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland.
Taniguchi H; Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, 1090 Vienna, Austria.

Int J Mol Sci ; 21(15)2020 Jul 29.

Article in En | MEDLINE | ID: mdl-32751080

Subject(s)

Carcinogenesis/genetics; Carcinoma, Hepatocellular/genetics; Gene Expression Regulation, Neoplastic; Kelch-Like ECH-Associated Protein 1/genetics; Liver Neoplasms/genetics; NF-E2-Related Factor 2/genetics; Transcriptional Activation; Carcinogenesis/metabolism; Carcinogenesis/pathology; Carcinoma, Hepatocellular/diagnosis; Carcinoma, Hepatocellular/mortality; Carcinoma, Hepatocellular/pathology; Cell Line, Tumor; Gene Regulatory Networks; Humans; Kelch-Like ECH-Associated Protein 1/metabolism; Liver Neoplasms/diagnosis; Liver Neoplasms/mortality; Liver Neoplasms/pathology; Mutation; NF-E2-Related Factor 2/metabolism; Oxidation-Reduction; Oxidative Stress; Prognosis; Signal Transduction; Survival Analysis

Key words

NF-E2-related factor 2; hepatocellular carcinoma; oxidative stress; redox homeostasis; transcription factor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Transcriptional Activation / Carcinoma, Hepatocellular / NF-E2-Related Factor 2 / Carcinogenesis / Kelch-Like ECH-Associated Protein 1 / Liver Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Poland

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