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ß-Catenin: oncogenic role and therapeutic target in cervical cancer.
Wang, Bingqi; Li, Xianping; Liu, Lei; Wang, Min.
Affiliation
  • Wang B; Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Li X; Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Liu L; Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Wang M; Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. wangmin0000@csu.edu.cn.
Biol Res ; 53(1): 33, 2020 Aug 05.
Article in En | MEDLINE | ID: mdl-32758292
ABSTRACT
Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneously by the host immune system; very few persist and eventually develop into cervical cancer. Therefore, other host or environmental alterations could also contribute to the malignant phenotype. One of the candidate co-factors is the ß-catenin protein, a pivotal component of the Wnt/ß-catenin signaling pathway. ß-Catenin mainly implicates two major cellular activities cell-cell adhesion and signal transduction. Recent studies have indicated that an imbalance in the structural and signaling properties of ß-catenin leads to various cancers, such as cervical cancer. In this review, we will systematically summarize the role of ß-catenin in cervical cancer and provide new insights into therapeutic strategies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Beta Catenin / Wnt Signaling Pathway / Carcinogenesis Limits: Female / Humans Language: En Journal: Biol Res Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Beta Catenin / Wnt Signaling Pathway / Carcinogenesis Limits: Female / Humans Language: En Journal: Biol Res Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: China