Carbazole-based fluorescent probes for G-quadruplex DNA targeting with superior selectivity and low cytotoxicity.

Yu, Quan-Qi; Wang, Ming-Qi

Yu, Quan-Qi; Wang, Ming-Qi.

Affiliation

Yu QQ; School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
Wang MQ; School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: wmq3415@163.com.

Bioorg Med Chem ; 28(17): 115641, 2020 09 01.

Article in En | MEDLINE | ID: mdl-32773092

Subject(s)

Carbazoles/chemistry; Fluorescent Dyes/pharmacology; G-Quadruplexes/drug effects; Binding Sites; Cell Line; Cell Survival/drug effects; Fluorescent Dyes/chemistry; Hemin/antagonists & inhibitors; Hemin/metabolism; Humans; Microscopy, Confocal; Molecular Docking Simulation; Nucleic Acid Conformation; Proto-Oncogene Proteins c-myc/genetics; Spectrometry, Fluorescence

Key words

Carbazole; Cell imaging; Cytotoxicity; Fluorescent probe; G-quadruplex DNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbazoles / G-Quadruplexes / Fluorescent Dyes Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article

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