C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury.

Sears, Sophia M; Sharp, Cierra N; Krueger, Austin; Oropilla, Gabrielle B; Saforo, Douglas; Doll, Mark A; Megyesi, Judit; Beverly, Levi J; Siskind, Leah J

Sears, Sophia M; Sharp, Cierra N; Krueger, Austin; Oropilla, Gabrielle B; Saforo, Douglas; Doll, Mark A; Megyesi, Judit; Beverly, Levi J; Siskind, Leah J.

Affiliation

Sears SM; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Sharp CN; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Krueger A; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Oropilla GB; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Saforo D; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Doll MA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Megyesi J; University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Beverly LJ; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky.
Siskind LJ; Department of Medicine, University of Louisville, Louisville, Kentucky.

Am J Physiol Renal Physiol ; 319(4): F674-F685, 2020 10 01.

Article in En | MEDLINE | ID: mdl-32830540

Subject(s)

Acute Kidney Injury/chemically induced; Chemokine CCL2/metabolism; Cisplatin; Kidney/metabolism; Acute Kidney Injury/immunology; Acute Kidney Injury/metabolism; Acute Kidney Injury/pathology; Animals; Apoptosis; Chemokine CCL2/genetics; Chemotaxis, Leukocyte; Disease Models, Animal; Endoplasmic Reticulum Stress; Fibrosis; Kidney/immunology; Kidney/pathology; Macrophages/immunology; Macrophages/metabolism; Male; Mice, Inbred C57BL; Monocytes/immunology; Monocytes/metabolism; Necrosis; Signal Transduction; Species Specificity

Key words

C-C motif chemokine ligand 2; acute kidney injury; chronic kidney disease; cisplatin; fibrosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Chemokine CCL2 / Acute Kidney Injury / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2020 Type: Article

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