Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting.

Robson, Fran; Khan, Khadija Shahed; Le, Thi Khanh; Paris, Clément; Demirbag, Sinem; Barfuss, Peter; Rocchi, Palma; Ng, Wai-Lung

Robson, Fran; Khan, Khadija Shahed; Le, Thi Khanh; Paris, Clément; Demirbag, Sinem; Barfuss, Peter; Rocchi, Palma; Ng, Wai-Lung.

Affiliation

Robson F; School of Biological Sciences, University of Bristol, Bristol, UK.
Khan KS; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Le TK; Life Science Department, University of Science and Technology of Hanoi (USTH), Hanoi, Vietnam; Centre de Recherche en Cancérologie de Marseille, CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University U105, Institut Paoli-Calmettes, Marseille, France.
Paris C; Centre de Recherche en Cancérologie de Marseille, CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University U105, Institut Paoli-Calmettes, Marseille, France.
Demirbag S; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey.
Barfuss P; Université Paris-Est, Cermics (ENPC), INRIA, 77455 Marne-la-Vallée, France.
Rocchi P; Centre de Recherche en Cancérologie de Marseille, CRCM, Inserm UMR1068, CNRS UMR7258, Aix-Marseille University U105, Institut Paoli-Calmettes, Marseille, France.
Ng WL; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: billyng@cuhk.edu.hk.

Mol Cell ; 79(5): 710-727, 2020 09 03.

Article in En | MEDLINE | ID: mdl-32853546

Subject(s)

Antiviral Agents/therapeutic use; Betacoronavirus/drug effects; Coronavirus Infections/drug therapy; Coronavirus Infections/epidemiology; Genome, Viral; Pandemics; Pneumonia, Viral/drug therapy; Pneumonia, Viral/epidemiology; RNA, Viral/genetics; Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/chemistry; Adenosine Monophosphate/therapeutic use; Alanine/analogs & derivatives; Alanine/chemistry; Alanine/therapeutic use; Amides/chemistry; Amides/therapeutic use; Antiviral Agents/chemistry; Betacoronavirus/genetics; Betacoronavirus/pathogenicity; COVID-19; Coronavirus Infections/virology; Cytidine/analogs & derivatives; Humans; Hydroxylamines; Molecular Targeted Therapy/methods; Mutation; Pneumonia, Viral/virology; Pyrazines/chemistry; Pyrazines/therapeutic use; RNA, Viral/antagonists & inhibitors; RNA, Viral/metabolism; Ribonucleosides/chemistry; Ribonucleosides/therapeutic use; SARS-CoV-2; Severity of Illness Index; Transcription, Genetic; Viral Nonstructural Proteins/antagonists & inhibitors; Viral Nonstructural Proteins/genetics; Viral Nonstructural Proteins/metabolism; Virus Replication/drug effects

Key words

ASO; CoV; ExoN; NA; anti-coronavirus drugs; antisense oligonucleotide; coronavirus; exonuclease; non-structural protein 14; nsp14; nucleoside analog

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / RNA, Viral / Genome, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: United kingdom

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