Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Mallone, Roberto; Eizirik, Decio L

Mallone, Roberto; Eizirik, Decio L.

Affiliation

Mallone R; Université de Paris, Institut Cochin, CNRS, INSERM, G.H. Cochin-Port Royal, Cassini building, 123 boulevard de Port Royal, 75014, Paris, France. roberto.mallone@inserm.fr.
Eizirik DL; Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaires de Paris Centre-Université de Paris, Cochin Hospital, Service de Diabétologie et Immunologie Clinique, 75014, Paris, France. roberto.mallone@inserm.fr.

Diabetologia ; 63(10): 1999-2006, 2020 10.

Article in En | MEDLINE | ID: mdl-32894310

Subject(s)

Autoimmunity/immunology; CD8-Positive T-Lymphocytes/immunology; Diabetes Mellitus, Type 1/metabolism; Insulin-Secreting Cells/metabolism; Insulin/biosynthesis; Secretory Vesicles/metabolism; Diabetes Mellitus, Type 1/genetics; Diabetes Mellitus, Type 1/immunology; Genetic Predisposition to Disease; Humans; Inflammation; Insulin/metabolism; Insulin Secretion; Insulin-Secreting Cells/immunology; Proinsulin/biosynthesis; Unfolded Protein Response/immunology

Key words

Antigen; Autoimmunity; Benign; Coxsackievirus; Endotype; Epitope; Islet; Proinsulin; Review; T cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmunity / CD8-Positive T-Lymphocytes / Secretory Vesicles / Diabetes Mellitus, Type 1 / Insulin-Secreting Cells / Insulin Limits: Humans Language: En Journal: Diabetologia Year: 2020 Type: Article Affiliation country: France

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