Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells.

Sancey, Lucie; Sabido, Odile; He, Zhiguo; Rossetti, Fabien; Guignandon, Alain; Bin, Valérie; Coll, Jean-Luc; Cottier, Michèle; Lux, François; Tillement, Olivier; Constant, Samuel; Mas, Christophe; Boudard, Delphine

Sancey, Lucie; Sabido, Odile; He, Zhiguo; Rossetti, Fabien; Guignandon, Alain; Bin, Valérie; Coll, Jean-Luc; Cottier, Michèle; Lux, François; Tillement, Olivier; Constant, Samuel; Mas, Christophe; Boudard, Delphine.

Affiliation

Sancey L; Institute for Advanced Biosciences, INSERM U1209, CNRS, UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France. lucie.sancey@univ-grenoble-alpes.fr.
Sabido O; INSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
He Z; Université de Lyon, Saint-Etienne, France.
Rossetti F; Université de Lyon, Saint-Etienne, France.
Guignandon A; , BiiGC EA2521, Saint-Etienne, France.
Bin V; Institut Lumière Matière, CNRS UMR5306, Université Lyon 1, 69100, Villeurbanne, France.
Coll JL; Université de Lyon, Saint-Etienne, France.
Cottier M; SAINBIOSE, Inserm U1059, LBTO Team, Saint-Etienne, France.
Lux F; INSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
Tillement O; Université de Lyon, Saint-Etienne, France.
Constant S; Institute for Advanced Biosciences, INSERM U1209, CNRS, UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France.
Mas C; INSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
Boudard D; Université de Lyon, Saint-Etienne, France.

J Nanobiotechnology ; 18(1): 129, 2020 Sep 10.

Article in En | MEDLINE | ID: mdl-32912214

Subject(s)

Epithelium/drug effects; Gadolinium/therapeutic use; Nanoparticles/therapeutic use; Respiratory System/drug effects; A549 Cells/pathology; Animals; Cell Culture Techniques; Cell Cycle; Cell Proliferation; Drug Delivery Systems/methods; Gadolinium/chemistry; Humans; Lung; Lung Neoplasms/drug therapy; Nanoparticles/chemistry

Key words

3D human healthy and tumor airway models; AGuIX® nanoparticles; Nanoparticle's toxicity; Nanoparticle's uptake; Tumor targeting

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Epithelium / Nanoparticles / Gadolinium Limits: Animals / Humans Language: En Journal: J Nanobiotechnology Year: 2020 Type: Article Affiliation country: France

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