ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP.

Fan, Huijuan; Wang, Xuxiang; Li, Wenyang; Shen, Minhong; Wei, Yong; Zheng, Hanqiu; Kang, Yibin

Fan, Huijuan; Wang, Xuxiang; Li, Wenyang; Shen, Minhong; Wei, Yong; Zheng, Hanqiu; Kang, Yibin.

Affiliation

Fan H; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Wang X; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Li W; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Shen M; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Wei Y; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Zheng H; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Kang Y; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

Genes Dev ; 34(19-20): 1359-1372, 2020 10 01.

Article in En | MEDLINE | ID: mdl-32943576

Subject(s)

Breast Neoplasms/physiopathology; Gene Expression Regulation, Neoplastic/genetics; Neoplasm Metastasis/physiopathology; Proteolysis; Proto-Oncogene Proteins c-yes/genetics; Snail Family Transcription Factors/metabolism; Breast Neoplasms/genetics; Cell Line, Tumor; Cell Movement/genetics; Female; Genome-Wide Association Study; Humans; Neoplasm Metastasis/genetics; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Ubiquitin-Protein Ligases/metabolism; Ubiquitination/genetics

Key words

ASB13; HippoYAP pathway; SNAI2; breast cancer; metastasis; migration; ubiquitin proteasome system

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-yes / Proteolysis / Snail Family Transcription Factors / Neoplasm Metastasis Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: China

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