Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells.

Wang, Xin-Yi; Sun, Gui-Bin; Wang, Ya-Jing; Yan, Fang

Wang, Xin-Yi; Sun, Gui-Bin; Wang, Ya-Jing; Yan, Fang.

Affiliation

Wang XY; Department of Pharmaceutical Analysis, School of pharmacology, China Pharmaceutical University.
Sun GB; Nanjing Syrois Pharmaceutical Co., Ltd.
Wang YJ; Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University.
Yan F; Department of Pharmaceutical Analysis, School of pharmacology, China Pharmaceutical University.

Biol Pharm Bull ; 43(10): 1526-1533, 2020.

Article in En | MEDLINE | ID: mdl-32999163

Subject(s)

Drug Resistance, Neoplasm/drug effects; Emodin/pharmacology; Genes, abl/drug effects; Imatinib Mesylate/pharmacology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; STAT5 Transcription Factor/antagonists & inhibitors; Allosteric Regulation/drug effects; Allosteric Regulation/physiology; Dose-Response Relationship, Drug; Down-Regulation/drug effects; Down-Regulation/physiology; Drug Resistance, Multiple/drug effects; Drug Resistance, Multiple/physiology; Drug Resistance, Neoplasm/physiology; Emodin/therapeutic use; Genes, abl/physiology; Humans; Imatinib Mesylate/therapeutic use; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Molecular Docking Simulation/methods; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein Structure, Secondary; STAT5 Transcription Factor/metabolism

Key words

allosteric inhibition; breakpoint cluster region-abelson tyrosine kinase; chronic myeloid leukemia; emodin; imatinib-resistance; signal transducer and activator of transcription 5

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Genes, abl / Emodin / Drug Resistance, Neoplasm / STAT5 Transcription Factor / Imatinib Mesylate Limits: Humans Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2020 Type: Article

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