c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.

Deville, Sara Sofia; Delgadillo Silva, Luis Fernando; Vehlow, Anne; Cordes, Nils

Deville, Sara Sofia; Delgadillo Silva, Luis Fernando; Vehlow, Anne; Cordes, Nils.

Affiliation

Deville SS; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Delgadillo Silva LF; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiooncology-OncoRay, 01328 Dresden, Germany.
Vehlow A; Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01307 Dresden, Germany.
Cordes N; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

Int J Mol Sci ; 21(19)2020 Oct 01.

Article in En | MEDLINE | ID: mdl-33019757

Subject(s)

Ataxia Telangiectasia Mutated Proteins/genetics; DNA Repair; DNA, Neoplasm/genetics; Gene Expression Regulation, Neoplastic; Intermediate Filament Proteins/genetics; Proto-Oncogene Proteins c-abl/genetics; Animals; Ataxia Telangiectasia Mutated Proteins/metabolism; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation/radiation effects; DNA Breaks, Double-Stranded; DNA, Neoplasm/metabolism; Embryo, Nonmammalian; Head and Neck Neoplasms/genetics; Head and Neck Neoplasms/metabolism; Head and Neck Neoplasms/pathology; Head and Neck Neoplasms/radiotherapy; Humans; Intermediate Filament Proteins/antagonists & inhibitors; Intermediate Filament Proteins/metabolism; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-abl/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Radiation Tolerance/genetics; Signal Transduction; Squamous Cell Carcinoma of Head and Neck/genetics; Squamous Cell Carcinoma of Head and Neck/metabolism; Squamous Cell Carcinoma of Head and Neck/pathology; Squamous Cell Carcinoma of Head and Neck/radiotherapy; X-Rays; Zebrafish

Key words

DNA repair; HNSCC; c-Abl; ionizing radiation; synemin; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Neoplasm / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-abl / DNA Repair / Ataxia Telangiectasia Mutated Proteins / Intermediate Filament Proteins Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Germany

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