Your browser doesn't support javascript.
loading
"Borderline" idiopathic CD4+ T-cell lymphocytopenia presenting with atypical progressive multifocal leukoencephalopathy.
Dato, Clemente; Elefante, Andrea; Coppola, Cinzia; Melone, Mariarosa Anna Beatrice; Lus, Giacomo; Costagliola, Antonella; Bruno, Giorgia; Puoti, Gianfranco.
Affiliation
  • Dato C; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy.
  • Elefante A; Department of Advanced Biomedical Sciences, University of Naples "Federico II", via Pansini 5, 80131 Naples, Italy. Electronic address: andrea.elefante@unina.it.
  • Coppola C; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy. Electronic address: cinzia.coppola@unicampania.it.
  • Melone MAB; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy. Electronic address: marina.melone@unicampania.it.
  • Lus G; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy. Electronic address: giacomo.lus@unicampania.it.
  • Costagliola A; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy.
  • Bruno G; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy.
  • Puoti G; Department of Advanced Medical and Surgical Sciences, Second Division of Neurology - University of Campania "Luigi Vanvitelli", via Pansini 5, 80131 Naples, Italy. Electronic address: gianfranco.puoti@unicampania.it.
J Neuroimmunol ; 349: 577420, 2020 12 15.
Article in En | MEDLINE | ID: mdl-33032014
ABSTRACT
Idiopathic CD4+ lymphocytopenia (ICL) is a rare disorder characterized by low counts of CD4+ cells (<300/mm3) in absence of other known causes of immunosuppression. A few cases of progressive multifocal leukoencephalopathy (PML) were reported in association with ICL with variable outcome. We describe the case of a 40 year-old man diagnosed with PML, which showed a monophasic course. Causes of primary and secondary immunodeficiency were ruled out, only a "borderline" ICL was found. This case highlights that a severe immunodepression could not be an absolute prerequisite in developing PML and also points the attention on current definition of ICL.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukoencephalopathy, Progressive Multifocal / T-Lymphocytopenia, Idiopathic CD4-Positive Type of study: Diagnostic_studies Limits: Adult / Humans / Male Language: En Journal: J Neuroimmunol Year: 2020 Type: Article Affiliation country: Italy
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukoencephalopathy, Progressive Multifocal / T-Lymphocytopenia, Idiopathic CD4-Positive Type of study: Diagnostic_studies Limits: Adult / Humans / Male Language: En Journal: J Neuroimmunol Year: 2020 Type: Article Affiliation country: Italy