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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
Jain, Siddhant U; Rashoff, Andrew Q; Krabbenhoft, Samuel D; Hoelper, Dominik; Do, Truman J; Gibson, Tyler J; Lundgren, Stefan M; Bondra, Eliana R; Deshmukh, Shriya; Harutyunyan, Ashot S; Juretic, Nikoleta; Jabado, Nada; Harrison, Melissa M; Lewis, Peter W.
Affiliation
  • Jain SU; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Rashoff AQ; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Krabbenhoft SD; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Hoelper D; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Do TJ; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Gibson TJ; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Lundgren SM; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Bondra ER; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Deshmukh S; Department of Experimental Medicine, McGill University, Montreal, QC, Canada.
  • Harutyunyan AS; Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Department of Pediatrics, McGill University and The Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada.
  • Juretic N; Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Department of Pediatrics, McGill University and The Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada.
  • Jabado N; Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Department of Pediatrics, McGill University and The Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada.
  • Harrison MM; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
  • Lewis PW; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA. Electronic address: peter.lewis@wisc.edu.
Mol Cell ; 80(4): 726-735.e7, 2020 11 19.
Article in En | MEDLINE | ID: mdl-33049227
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Histones / Gene Expression Regulation, Neoplastic / Oncogene Proteins / DNA Methylation / Polycomb Repressive Complex 2 / Mutation Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Histones / Gene Expression Regulation, Neoplastic / Oncogene Proteins / DNA Methylation / Polycomb Repressive Complex 2 / Mutation Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: United States