Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from <i>Thermotoga maritima</i>.

Smaldone, Giovanni; Ruggiero, Alessia; Balasco, Nicole; Vitagliano, Luigi

Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima.

Smaldone, Giovanni; Ruggiero, Alessia; Balasco, Nicole; Vitagliano, Luigi.

Affiliation

Smaldone G; IRCCS SDN, Via Emanuele Gianturco, 113 80143 Naples, Italy.
Ruggiero A; Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16. I-80134 Naples, Italy.
Balasco N; Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16. I-80134 Naples, Italy.
Vitagliano L; Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16. I-80134 Naples, Italy.

Int J Mol Sci ; 21(20)2020 Oct 12.

Article in En | MEDLINE | ID: mdl-33053818

Subject(s)

Arginine/chemistry; Arginine/metabolism; Bacterial Physiological Phenomena; Carrier Proteins/chemistry; Carrier Proteins/metabolism; Thermotoga maritima/metabolism; Carrier Proteins/genetics; Hyperargininemia/diagnosis; Hyperargininemia/etiology; Hyperargininemia/metabolism; Ligands; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Structure-Activity Relationship; Thermotoga maritima/genetics

Key words

argininemia diagnosis; biosensors; crystal structure; protein dissection; protein scaffolds; protein stability

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Carrier Proteins / Bacterial Physiological Phenomena / Thermotoga maritima Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Italy

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