Testosterone replacement therapy in blood donors modulates erythrocyte metabolism and susceptibility to hemolysis in cold storage.

Alexander, Keisha; Hazegh, Kelsey; Fang, Fang; Sinchar, Derek; Kiss, Joseph E; Page, Grier P; DÊ¼Alessandro, Angelo; Kanias, Tamir

Alexander, Keisha; Hazegh, Kelsey; Fang, Fang; Sinchar, Derek; Kiss, Joseph E; Page, Grier P; DÊ¼Alessandro, Angelo; Kanias, Tamir.

Affiliation

Alexander K; Department of Biochemistry and Molecular Genetics, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.
Hazegh K; Vitalant Research Institute, Denver, Colorado, USA.
Fang F; RTI International, Research Triangle Park, North Carolina, USA.
Sinchar D; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kiss JE; Vitalant, Pittsburgh, Pennsylvania, USA.
Page GP; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
DÊ¼Alessandro A; RTI International, Atlanta, Georgia, USA.
Kanias T; Department of Biochemistry and Molecular Genetics, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.

Transfusion ; 61(1): 108-123, 2021 01.

Article in En | MEDLINE | ID: mdl-33073382

Subject(s)

Blood Preservation/methods; Carnitine/analogs & derivatives; Erythrocytes/drug effects; Erythrocytes/metabolism; Hemolysis/physiology; Testosterone/deficiency; Testosterone/pharmacology; Animals; Arginine/blood; Blood Donors; Carnitine/blood; Chromatography, High Pressure Liquid; Cohort Studies; Correlation of Data; Dopamine/blood; Erucic Acids/blood; Fatty Acids/blood; Female; Glutathione/blood; Hormone Replacement Therapy; Humans; Male; Mass Spectrometry; Metabolic Networks and Pathways/drug effects; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pentose Phosphate Pathway/physiology; Purines/blood; Tumor Protein, Translationally-Controlled 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Testosterone / Blood Preservation / Carnitine / Erythrocytes / Hemolysis Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Transfusion Year: 2021 Type: Article Affiliation country: United States

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