A Villin-Driven Fxr Transgene Modulates Enterohepatic Bile Acid Homeostasis and Response to an n-6-Enriched High-Fat Diet.

Wren, Spencer N; Donovan, Micah G; Selmin, Ornella I; Doetschman, Tom C; Romagnolo, Donato F

A Villin-Driven Fxr Transgene Modulates Enterohepatic Bile Acid Homeostasis and Response to an n-6-Enriched High-Fat Diet.

Wren, Spencer N; Donovan, Micah G; Selmin, Ornella I; Doetschman, Tom C; Romagnolo, Donato F.

Affiliation

Wren SN; Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA.
Donovan MG; Interdisciplinary Cancer Biology Graduate Program, The University of Arizona, Tucson, AZ 85724, USA.
Selmin OI; Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA.
Doetschman TC; The University of Arizona Cancer Center, Tucson, AZ 85724, USA.
Romagnolo DF; Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, AZ 85724, USA.

Int J Mol Sci ; 21(21)2020 Oct 22.

Article in En | MEDLINE | ID: mdl-33105708

Subject(s)

Bile Acids and Salts/metabolism; Diet, High-Fat/adverse effects; Fatty Acids, Omega-6/pharmacology; RNA-Binding Proteins/genetics; Animals; Bile Acids and Salts/genetics; Body Weight/drug effects; Body Weight/genetics; Cecum/metabolism; Female; Gene Expression; Homeostasis/drug effects; Homeostasis/genetics; Linoleic Acid/pharmacology; Liver/metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins/genetics; Transgenes

Key words

bile acids; farnesoid X receptor; high-fat diet; linoleic acid; n-6; soybean oil

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / RNA-Binding Proteins / Fatty Acids, Omega-6 / Diet, High-Fat Limits: Animals Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: United States

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