Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.

Gaullier, Guillaume; Roberts, Genevieve; Muthurajan, Uma M; Bowerman, Samuel; Rudolph, Johannes; Mahadevan, Jyothi; Jha, Asmita; Rae, Purushka S; Luger, Karolin

Gaullier, Guillaume; Roberts, Genevieve; Muthurajan, Uma M; Bowerman, Samuel; Rudolph, Johannes; Mahadevan, Jyothi; Jha, Asmita; Rae, Purushka S; Luger, Karolin.

Affiliation

Gaullier G; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Roberts G; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Muthurajan UM; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Bowerman S; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Rudolph J; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Mahadevan J; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Jha A; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.
Rae PS; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Luger K; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, United States of America.

PLoS One ; 15(11): e0240932, 2020.

Article in En | MEDLINE | ID: mdl-33141820

Subject(s)

Carrier Proteins/metabolism; DNA Breaks, Double-Stranded; Nuclear Proteins/metabolism; Poly(ADP-ribose) Polymerases/metabolism; Amino Acid Substitution; Carrier Proteins/chemistry; Carrier Proteins/genetics; Cryoelectron Microscopy; Humans; In Vitro Techniques; Models, Molecular; Mutant Proteins/chemistry; Mutant Proteins/genetics; Mutant Proteins/metabolism; Nuclear Proteins/chemistry; Nuclear Proteins/genetics; Nucleosomes/metabolism; Nucleosomes/ultrastructure; Point Mutation; Poly(ADP-ribose) Polymerases/chemistry; Poly(ADP-ribose) Polymerases/genetics; Protein Binding; Protein Conformation; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Carrier Proteins / Poly(ADP-ribose) Polymerases / DNA Breaks, Double-Stranded Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2020 Type: Article Affiliation country: United States

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