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Review and Consensus on Pharmacogenomic Testing in Psychiatry.
Bousman, Chad A; Bengesser, Susanne A; Aitchison, Katherine J; Amare, Azmeraw T; Aschauer, Harald; Baune, Bernhard T; Asl, Bahareh Behroozi; Bishop, Jeffrey R; Burmeister, Margit; Chaumette, Boris; Chen, Li-Shiun; Cordner, Zachary A; Deckert, Jürgen; Degenhardt, Franziska; DeLisi, Lynn E; Folkersen, Lasse; Kennedy, James L; Klein, Teri E; McClay, Joseph L; McMahon, Francis J; Musil, Richard; Saccone, Nancy L; Sangkuhl, Katrin; Stowe, Robert M; Tan, Ene-Choo; Tiwari, Arun K; Zai, Clement C; Zai, Gwyneth; Zhang, Jianping; Gaedigk, Andrea; Müller, Daniel J.
Affiliation
  • Bousman CA; Departments of Medical Genetics, Psychiatry, Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
  • Bengesser SA; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Aitchison KJ; Alberta Children's Hospital Research Institute, Calgary, AB, Canada.
  • Amare AT; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia.
  • Aschauer H; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Austria.
  • Baune BT; Departments of Psychiatry, Medical Genetics and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
  • Asl BB; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
  • Bishop JR; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
  • Burmeister M; Biopsychosocial Corporation (BioPsyC), non-profit association, Vienna, Austria.
  • Chaumette B; Department of Psychiatry and Psychotherapy, University of Münster, Germany.
  • Chen LS; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia.
  • Cordner ZA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
  • Deckert J; Departments of Psychiatry, Medical Genetics and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
  • Degenhardt F; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy and Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA.
  • DeLisi LE; Michigan Neuroscience Institute and Departments of Computational Medicine & Bioinformatics, Human Genetics and Psychiatry, The University of Michigan, Ann Arbor MI, USA.
  • Folkersen L; Institute of Psychiatry and Neuroscience of Paris, GHU Paris Psychiatrie & Neurosciences, University of Paris, Paris, France.
  • Kennedy JL; Department of Psychiatry, McGill University, Montreal, Canada.
  • Klein TE; Departments of Psychiatry and Genetics, Washington University School of Medicine in St. Louis, USA.
  • McClay JL; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • McMahon FJ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, Würzburg, Germany.
  • Musil R; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Saccone NL; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
  • Sangkuhl K; Department of Psychiatry, Harvard Medical School, Cambridge Health Alliance, Cambridge, Massachusetts, USA.
  • Stowe RM; Institute of Biological Psychiatry, Capital Region Hospitals, Copenhagen, Denmark.
  • Tan EC; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Tiwari AK; Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
  • Zai CC; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Zai G; Department of Pharmacotherapy and Outcome Science, Virginia Commonwealth University School of Pharmacy, Richmond, VA, USA.
  • Zhang J; Human Genetics Branch, National Institute of Mental Health, Bethesda, MD, USA.
  • Gaedigk A; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
  • Müller DJ; Departments of Psychiatry and Genetics, Washington University School of Medicine in St. Louis, USA.
Pharmacopsychiatry ; 54(1): 5-17, 2021 Jan.
Article in En | MEDLINE | ID: mdl-33147643
ABSTRACT
The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part due to divergent perceptions of the quality and completeness of the evidence base and diverse perspectives on the clinical utility of PGx testing among psychiatrists and other healthcare providers. Recognizing the current lack of consensus within the field, the International Society of Psychiatric Genetics assembled a group of experts to conduct a narrative synthesis of the PGx literature, prescribing guidelines, and product labels related to psychotropic medications as well as the key considerations and limitations related to the use of PGx testing in psychiatry. The group concluded that to inform medication selection and dosing of several commonly-used antidepressant and antipsychotic medications, current published evidence, prescribing guidelines, and product labels support the use of PGx testing for 2 cytochrome P450 genes (CYP2D6, CYP2C19). In addition, the evidence supports testing for human leukocyte antigen genes when using the mood stabilizers carbamazepine (HLA-A and HLA-B), oxcarbazepine (HLA-B), and phenytoin (CYP2C9, HLA-B). For valproate, screening for variants in certain genes (POLG, OTC, CSP1) is recommended when a mitochondrial disorder or a urea cycle disorder is suspected. Although barriers to implementing PGx testing remain to be fully resolved, the current trajectory of discovery and innovation in the field suggests these barriers will be overcome and testing will become an important tool in psychiatry.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psychiatry / Antipsychotic Agents / Pharmacogenomic Testing / Antidepressive Agents Type of study: Guideline / Systematic_reviews Limits: Humans Language: En Journal: Pharmacopsychiatry Year: 2021 Type: Article Affiliation country: Canada
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psychiatry / Antipsychotic Agents / Pharmacogenomic Testing / Antidepressive Agents Type of study: Guideline / Systematic_reviews Limits: Humans Language: En Journal: Pharmacopsychiatry Year: 2021 Type: Article Affiliation country: Canada