Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats.

Pannala, Venkat R; Estes, Shanea K; Rahim, Mohsin; Trenary, Irina; O'Brien, Tracy P; Shiota, Chiyo; Printz, Richard L; Reifman, Jaques; Shiota, Masakazu; Young, Jamey D; Wallqvist, Anders

Pannala, Venkat R; Estes, Shanea K; Rahim, Mohsin; Trenary, Irina; O'Brien, Tracy P; Shiota, Chiyo; Printz, Richard L; Reifman, Jaques; Shiota, Masakazu; Young, Jamey D; Wallqvist, Anders.

Affiliation

Pannala VR; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA.
Estes SK; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
Rahim M; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Trenary I; Department of Chemical and Biomolecular Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232, USA.
O'Brien TP; Department of Chemical and Biomolecular Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232, USA.
Shiota C; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Printz RL; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Reifman J; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Shiota M; Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA.
Young JD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Wallqvist A; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Int J Mol Sci ; 21(21)2020 Nov 04.

Article in En | MEDLINE | ID: mdl-33158035

Subject(s)

Amino Acids/metabolism; Chemical and Drug Induced Liver Injury/diagnosis; Hazardous Substances/pharmacology; Lipid Metabolism/drug effects; Metabolome/drug effects; Acetaminophen/pharmacology; Acetaminophen/toxicity; Acute Disease; Animals; Biomarkers/analysis; Biomarkers/metabolism; Bromobenzenes/pharmacology; Bromobenzenes/toxicity; Carbon Tetrachloride/pharmacology; Carbon Tetrachloride/toxicity; Chemical and Drug Induced Liver Injury/genetics; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/pathology; Gene Expression Profiling; Hazardous Substances/toxicity; Hepatocytes/drug effects; Hepatocytes/metabolism; Hepatocytes/pathology; Lipid Metabolism/genetics; Liver/drug effects; Liver/metabolism; Liver/pathology; Male; Metabolic Networks and Pathways/drug effects; Metabolic Networks and Pathways/genetics; Metabolome/genetics; Metabolomics; Prognosis; Rats; Rats, Sprague-Dawley; Transcriptome/drug effects

Key words

and metabolomics; gene expression profiles; genome-scale metabolic models; hepatotoxicity; injury pathways; liver; mechanism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hazardous Substances / Lipid Metabolism / Metabolome / Chemical and Drug Induced Liver Injury / Amino Acids Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: United States

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