Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4<sup>+</sup> T Effector and Regulatory T Cells in Cutaneous Leishmaniasis.

de Freitas E Silva, Rafael; Gálvez, Rosa Isela; Pereira, Valéria Rego Alves; de Brito, Maria Edileuza Felinto; Choy, Siew Ling; Lotter, Hannelore; Bosurgi, Lidia; Jacobs, Thomas

Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4⁺ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis.

de Freitas E Silva, Rafael; Gálvez, Rosa Isela; Pereira, Valéria Rego Alves; de Brito, Maria Edileuza Felinto; Choy, Siew Ling; Lotter, Hannelore; Bosurgi, Lidia; Jacobs, Thomas.

Affiliation

de Freitas E Silva R; Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Gálvez RI; Department of Natural Sciences, University of Pernambuco, Garanhuns, Brazil.
Pereira VRA; Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
de Brito MEF; Department of Immunology, Aggeu Magalhães Institute-Oswaldo Cruz Foundation, Recife, Brazil.
Choy SL; Department of Immunology, Aggeu Magalhães Institute-Oswaldo Cruz Foundation, Recife, Brazil.
Lotter H; Department of Molecular Parasitology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Bosurgi L; Department of Molecular Parasitology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Jacobs T; Protozoa Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Front Immunol ; 11: 574491, 2020.

Article in En | MEDLINE | ID: mdl-33193363

Subject(s)

B7-H1 Antigen/immunology; CD4-Positive T-Lymphocytes/immunology; Leishmaniasis, Cutaneous/immunology; Programmed Cell Death 1 Receptor/immunology; T-Lymphocyte Subsets/immunology; Adolescent; Adult; Animals; B7-H1 Antigen/metabolism; CD4-Positive T-Lymphocytes/metabolism; Cytokines/metabolism; Female; Humans; Inflammation; Leishmania; Leishmaniasis, Cutaneous/blood; Leishmaniasis, Cutaneous/pathology; Lymph Nodes/immunology; Macrophages/immunology; Macrophages/metabolism; Male; Mice; Middle Aged; Monocytes/immunology; Monocytes/metabolism; Phenotype; Programmed Cell Death 1 Receptor/metabolism; T-Lymphocyte Subsets/metabolism; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism; Young Adult

Key words

CD4 T cell; PD-1 (CD279); PD-L1 (B7-H1 CD274); co-inhibitory receptors; leishmaniasis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets / Leishmaniasis, Cutaneous / B7-H1 Antigen / Programmed Cell Death 1 Receptor Limits: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Front Immunol Year: 2020 Type: Article Affiliation country: Germany

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