A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation.

Vallarola, Antonio; Tortarolo, Massimo; De Gioia, Roberta; Iamele, Luisa; de Jonge, Hugo; de Nola, Giovanni; Bovio, Enrica; Pasetto, Laura; Bonetto, Valentina; Freschi, Mattia; Bendotti, Caterina; Gherardi, Ermanno

Vallarola, Antonio; Tortarolo, Massimo; De Gioia, Roberta; Iamele, Luisa; de Jonge, Hugo; de Nola, Giovanni; Bovio, Enrica; Pasetto, Laura; Bonetto, Valentina; Freschi, Mattia; Bendotti, Caterina; Gherardi, Ermanno.

Affiliation

Vallarola A; Laboratory of Molecular Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Tortarolo M; Laboratory of Molecular Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
De Gioia R; Laboratory of Molecular Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Iamele L; Immunology and General Pathology Unit, Department of Molecular Medicine, Università di Pavia, 27100 Pavia, Italy.
de Jonge H; Immunology and General Pathology Unit, Department of Molecular Medicine, Università di Pavia, 27100 Pavia, Italy.
de Nola G; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Bovio E; Immunology and General Pathology Unit, Department of Molecular Medicine, Università di Pavia, 27100 Pavia, Italy.
Pasetto L; Laboratory of Translational Biomarkers, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Bonetto V; Laboratory of Translational Biomarkers, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Freschi M; Laboratory of Molecular Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Bendotti C; Laboratory of Molecular Neurobiology, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Gherardi E; Immunology and General Pathology Unit, Department of Molecular Medicine, Università di Pavia, 27100 Pavia, Italy.

Int J Mol Sci ; 21(22)2020 Nov 12.

Article in En | MEDLINE | ID: mdl-33198383

Subject(s)

Amyotrophic Lateral Sclerosis/metabolism; Hepatocyte Growth Factor/agonists; Immune System; Neurons/cytology; Amyotrophic Lateral Sclerosis/drug therapy; Amyotrophic Lateral Sclerosis/immunology; Animals; Astrocytes/cytology; Astrocytes/metabolism; Behavior, Animal; Cell Survival; Coculture Techniques; Disease Models, Animal; Disease Progression; Dogs; Extracellular Signal-Regulated MAP Kinases/metabolism; Gliosis/metabolism; Humans; Interleukin-4/metabolism; Kringles; Ligands; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia/metabolism; Motor Neurons/metabolism; Neurons/metabolism; Schwann Cells/metabolism; Spinal Cord/metabolism; T-Lymphocytes/cytology

Key words

HGF/SF; MET; SOD1G93A mice; T cells; amyotrophic lateral sclerosis; motor neurons; pERK

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocyte Growth Factor / Amyotrophic Lateral Sclerosis / Immune System / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Italy

Fulltext

XML

PubMed Links

Search on Google