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APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes.
Giarratana, Anna O; Zheng, Cynthia; Reddi, Sahithi; Teng, Shavonne L; Berger, David; Adler, Derek; Sullivan, Patrick; Thakker-Varia, Smita; Alder, Janet.
Affiliation
  • Giarratana AO; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA.
  • Zheng C; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA.
  • Reddi S; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA.
  • Teng SL; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA.
  • Berger D; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA.
  • Adler D; Rutgers Molecular Imaging Center, 41 Gordon Road, Suite D, Room 365A, Piscataway, NJ, 08854, USA.
  • Sullivan P; Division of Geriatrics, Department of Medicine, Durham VAMC, GRECC, Duke University, Durham, NC, USA.
  • Thakker-Varia S; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA.
  • Alder J; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Research Building 357A, Piscataway, NJ, 08854-5635, USA. janet.alder@rutgers.edu.
Sci Rep ; 10(1): 19919, 2020 11 16.
Article in En | MEDLINE | ID: mdl-33199792
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Brain Concussion / Disease Models, Animal / Apolipoprotein E4 / Bryostatins / Inflammation Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Brain Concussion / Disease Models, Animal / Apolipoprotein E4 / Bryostatins / Inflammation Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Sci Rep Year: 2020 Type: Article Affiliation country: United States