Diketoacetonylphenalenone, Derived from Hawaiian Volcanic Soil-Associated Fungus <i>Penicillium herquei</i> FT729, Regulates T Cell Activation via Nuclear Factor-&#954;B and Mitogen-Activated Protein Kinase Pathway.

Lee, Hyun-Su; Yu, Jae Sik; Kim, Ki Hyun; Jeong, Gil-Saeng

Diketoacetonylphenalenone, Derived from Hawaiian Volcanic Soil-Associated Fungus Penicillium herquei FT729, Regulates T Cell Activation via Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathway.

Lee, Hyun-Su; Yu, Jae Sik; Kim, Ki Hyun; Jeong, Gil-Saeng.

Affiliation

Lee HS; College of Pharmacy, Keimyung University, Daegu 42601, Korea.
Yu JS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Kim KH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jeong GS; College of Pharmacy, Keimyung University, Daegu 42601, Korea.

Molecules ; 25(22)2020 Nov 17.

Article in En | MEDLINE | ID: mdl-33212980

Subject(s)

Lymphocyte Activation/immunology; MAP Kinase Signaling System/drug effects; NF-kappa B/metabolism; Penicillium/chemistry; Polycyclic Aromatic Hydrocarbons/pharmacology; Soil Microbiology; T-Lymphocytes/immunology; Apoptosis/drug effects; Cell Proliferation/drug effects; Cytotoxicity, Immunologic/drug effects; Humans; I-kappa B Kinase/metabolism; Interleukin-2/biosynthesis; Jurkat Cells; Lymphocyte Activation/drug effects; MAP Kinase Kinase Kinases/metabolism; Polycyclic Aromatic Hydrocarbons/chemistry; T-Lymphocytes/drug effects

Key words

Penicillium herquei FT729; T cells; immunosuppressive

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Polycyclic Aromatic Hydrocarbons / Soil Microbiology / Lymphocyte Activation / T-Lymphocytes / NF-kappa B / MAP Kinase Signaling System Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2020 Type: Article

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