Synthesis and Structure-Activity Relationship of Xenocoumacin 1 and Analogues as Inhibitors of Ribosomal Protein Synthesis.

Zumbrunn, Cornelia; Krüsi, Daniela; Stamm, Christina; Caspers, Patrick; Ritz, Daniel; Rueedi, Georg

Zumbrunn, Cornelia; Krüsi, Daniela; Stamm, Christina; Caspers, Patrick; Ritz, Daniel; Rueedi, Georg.

Affiliation

Zumbrunn C; Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Krüsi D; Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Stamm C; Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Caspers P; Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Ritz D; Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Rueedi G; Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.

ChemMedChem ; 16(5): 891-897, 2021 03 03.

Article in En | MEDLINE | ID: mdl-33236408

Subject(s)

Anti-Bacterial Agents/pharmacology; Benzopyrans/pharmacology; Escherichia coli/drug effects; Ribosomal Proteins/antagonists & inhibitors; Anti-Bacterial Agents/chemistry; Benzopyrans/chemistry; Crystallography, X-Ray; Dose-Response Relationship, Drug; Escherichia coli/metabolism; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Ribosomal Proteins/biosynthesis; Structure-Activity Relationship

Key words

RNA recognition; antibiotics; natural products; protein synthesis inhibition; structure-activity relationships

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomal Proteins / Benzopyrans / Escherichia coli / Anti-Bacterial Agents Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2021 Type: Article Affiliation country: Switzerland

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