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History, presence, and future of mitomycin C in glaucoma filtration surgery.
Wolters, Jarno E J; van Mechelen, Ralph J S; Al Majidi, Rana; Pinchuk, Leonard; Webers, Carroll A B; Beckers, Henny J M; Gorgels, Theo G M F.
Affiliation
  • Wolters JEJ; University Eye Clinic Maastricht, Maastricht University Medical Centre + (MUMC+), Maastricht.
  • van Mechelen RJS; Chemelot Institute for Science and Technology (InSciTe), Geleen.
  • Al Majidi R; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
  • Pinchuk L; University Eye Clinic Maastricht, Maastricht University Medical Centre + (MUMC+), Maastricht.
  • Webers CAB; Chemelot Institute for Science and Technology (InSciTe), Geleen.
  • Beckers HJM; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
  • Gorgels TGMF; University Eye Clinic Maastricht, Maastricht University Medical Centre + (MUMC+), Maastricht.
Curr Opin Ophthalmol ; 32(2): 148-159, 2021 Mar 01.
Article in En | MEDLINE | ID: mdl-33315724
ABSTRACT
PURPOSE OF REVIEW Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis. By this virtue, MMC is an important antitumor drug. In addition, MMC has become the gold standard medication for glaucoma filtration surgery (GFS). This eye surgery creates a passage for drainage of aqueous humor (AqH) out of the eye into the sub-Tenon's space with the aim of lowering the intraocular pressure. A major cause of failure of this operation is fibrosis and scarring in the sub-Tenon's space, which will restrict AqH outflow. Intraoperative application of MMC during GFS has increased GFS success rate, presumably mainly by reducing fibrosis after GFS. However, still 10% of glaucoma surgeries fail within the first year. RECENT

FINDINGS:

In this review, we evaluate risks and benefits of MMC as an adjuvant for GFS. In addition, we discuss possible improvements of its use by adjusting dose and method of administration.

SUMMARY:

One way of improving GFS outcome is to prolong MMC delivery by using a drug delivery system.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sclera / Glaucoma / Mitomycin / Filtering Surgery / Alkylating Agents Limits: Humans Language: En Journal: Curr Opin Ophthalmol Journal subject: OFTALMOLOGIA Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sclera / Glaucoma / Mitomycin / Filtering Surgery / Alkylating Agents Limits: Humans Language: En Journal: Curr Opin Ophthalmol Journal subject: OFTALMOLOGIA Year: 2021 Type: Article