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Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.
Goedtke, Lisa; Sprenger, Heike; Hofmann, Ute; Schmidt, Felix F; Hammer, Helen S; Zanger, Ulrich M; Poetz, Oliver; Seidel, Albrecht; Braeuning, Albert; Hessel-Pras, Stefanie.
Affiliation
  • Goedtke L; Department Food Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.
  • Sprenger H; Department Food Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.
  • Hofmann U; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, and University of Tübingen, 72074 Tübingen, Germany.
  • Schmidt FF; SIGNATOPE GmbH, Markwiesenstraße 55, 72770 Reutlingen, Germany.
  • Hammer HS; SIGNATOPE GmbH, Markwiesenstraße 55, 72770 Reutlingen, Germany.
  • Zanger UM; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, and University of Tübingen, 72074 Tübingen, Germany.
  • Poetz O; SIGNATOPE GmbH, Markwiesenstraße 55, 72770 Reutlingen, Germany.
  • Seidel A; Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer Foundation, Lurup 4, 22927 Grosshansdorf, Germany.
  • Braeuning A; Department Food Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.
  • Hessel-Pras S; Department Food Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.
Int J Mol Sci ; 22(1)2020 Dec 31.
Article in En | MEDLINE | ID: mdl-33396476
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Aromatic Hydrocarbons / Xenobiotics / Gene Expression Regulation, Neoplastic / Receptors, Cytoplasmic and Nuclear / Receptors, Aryl Hydrocarbon / Carcinoma, Hepatocellular / Basic Helix-Loop-Helix Transcription Factors / Liver Neoplasms Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Aromatic Hydrocarbons / Xenobiotics / Gene Expression Regulation, Neoplastic / Receptors, Cytoplasmic and Nuclear / Receptors, Aryl Hydrocarbon / Carcinoma, Hepatocellular / Basic Helix-Loop-Helix Transcription Factors / Liver Neoplasms Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Germany