Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms.

Ng, Martin Y; Li, Hong; Ghelfi, Mikel D; Goldman, Yale E; Cooperman, Barry S

Ng, Martin Y; Li, Hong; Ghelfi, Mikel D; Goldman, Yale E; Cooperman, Barry S.

Affiliation

Ng MY; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104.
Li H; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104.
Ghelfi MD; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104.
Goldman YE; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Cooperman BS; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104; cooprman@sas.upenn.edu.

Proc Natl Acad Sci U S A ; 118(2)2021 01 12.

Article in En | MEDLINE | ID: mdl-33414181

Subject(s)

Aminoglycosides/pharmacology; Codon, Nonsense/drug effects; Oxadiazoles/pharmacology; Peptide Chain Elongation, Translational/drug effects; Aminoglycosides/metabolism; Animals; Artemia/genetics; Codon, Nonsense/metabolism; Codon, Terminator/drug effects; Codon, Terminator/metabolism; Cystic Fibrosis/genetics; Muscular Dystrophy, Duchenne/genetics; Oxadiazoles/metabolism; Protein Biosynthesis/drug effects; Protein Synthesis Inhibitors; RNA, Transfer/drug effects; RNA, Transfer/genetics; RNA, Transfer/metabolism; Ribosomes/drug effects; Saccharomyces/genetics

Key words

G418; TRID; ataluren; nonsense suppression; read-through

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Peptide Chain Elongation, Translational / Codon, Nonsense / Aminoglycosides Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article

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