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Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target.
Chen, Ernie; Chuang, Ling-Shiang; Giri, Mamta; Villaverde, Nicole; Hsu, Nai-Yun; Sabic, Ksenija; Joshowitz, Sari; Gettler, Kyle; Nayar, Shikha; Chai, Zhi; Alter, Isaac L; Chasteau, Colleen C; Korie, Ujunwa M; Dzedzik, Siarhei; Thin, Tin Htwe; Jain, Aayushee; Moscati, Arden; Bongers, Gerardus; Duerr, Richard H; Silverberg, Mark S; Brant, Steven R; Rioux, John D; Peter, Inga; Schumm, L Philip; Haritunians, Talin; McGovern, Dermot P; Itan, Yuval; Cho, Judy H.
Affiliation
  • Chen E; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Chuang LS; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Giri M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Villaverde N; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Hsu NY; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Sabic K; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Joshowitz S; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Gettler K; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Nayar S; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Chai Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York.
  • Alter IL; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York.
  • Chasteau CC; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Korie UM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Dzedzik S; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York.
  • Thin TH; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York.
  • Jain A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Moscati A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Bongers G; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York.
  • Duerr RH; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Silverberg MS; Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Ontario, Canada, Toronto, Ontario, Canada.
  • Brant SR; Crohns and Colitis Center of New Jersey, Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
  • Rioux JD; Research Centre, Montreal Heart Institute, Montréal, Quebec, Canada; Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.
  • Peter I; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Schumm LP; Department of Health Sciences, University of Chicago, Chicago, Illinois.
  • Haritunians T; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • McGovern DP; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Itan Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.
  • Cho JH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York. Electronic address: Judy.cho@mssm.edu.
Gastroenterology ; 160(5): 1709-1724, 2021 04.
Article in En | MEDLINE | ID: mdl-33421512
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Cell Degranulation / Receptors, Neuropeptide / Colon / Receptors, G-Protein-Coupled / Mast Cells / Nerve Tissue Proteins Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Cell Degranulation / Receptors, Neuropeptide / Colon / Receptors, G-Protein-Coupled / Mast Cells / Nerve Tissue Proteins Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2021 Type: Article