Roles of the BAP1 Tumor Suppressor in Cell Metabolism.
Cancer Res
; 81(11): 2807-2814, 2021 06 01.
Article
in En
| MEDLINE
| ID: mdl-33446574
ABSTRACT
BRCA1-associated protein 1 (BAP1) is emerging as an intensively studied cancer-associated gene. Germline mutations in BAP1 lead to a cancer syndrome, and somatic loss is found in several cancer types. BAP1 encodes a deubiquitinase enzyme, which plays key roles in cell-cycle regulation, cell death, and differentiation. Recent studies have demonstrated that BAP1 is also involved in several aspects of cellular metabolism, including metabolic homeostasis, glucose utilization, control of ferroptosis, and stress response. A better knowledge of the metabolic roles of cancer-associated genes is important to understanding tumor initiation and progression, as well as highlighting potential therapeutic avenues. With this review, we summarize the current knowledge regarding BAP1-mediated regulation of metabolic activities that may support new strategies to treat BAP1-mutated cancers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, Tumor Suppressor
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Germ-Line Mutation
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Tumor Suppressor Proteins
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Ubiquitin Thiolesterase
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Homeostasis
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Neoplasms
Limits:
Humans
Language:
En
Journal:
Cancer Res
Year:
2021
Type:
Article