Next-generation sequencing analysis suggests varied multistep mutational pathogenesis for endocrine mucin-producing sweat gland carcinoma with comments on INSM1 and MUC2 suggesting a conjunctival origin.

Mathew, Joseph G; Bowman, Anita S; Saab, Jad; Busam, Klaus J; Nehal, Kishwer; Pulitzer, Melissa

Mathew, Joseph G; Bowman, Anita S; Saab, Jad; Busam, Klaus J; Nehal, Kishwer; Pulitzer, Melissa.

Affiliation

Mathew JG; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Bowman AS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Saab J; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Busam KJ; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nehal K; Department of Medicine, Dermatology Division, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Pulitzer M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: pulitzem@mskcc.org.

J Am Acad Dermatol ; 86(5): 1072-1079, 2022 05.

Article in En | MEDLINE | ID: mdl-33515627

Subject(s)

Carcinoma, Skin Appendage; Insulinoma; Merkel cell polyomavirus; Pancreatic Neoplasms; Skin Neoplasms; Sweat Gland Neoplasms; Aged; Aged, 80 and over; Biomarkers, Tumor/analysis; Biomarkers, Tumor/genetics; Cell Cycle Proteins; Female; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Mucin-2/genetics; Mucin-2/metabolism; Mucin-4/genetics; Mucins/metabolism; Mutation; Nuclear Proteins/genetics; Protein Serine-Threonine Kinases; Receptors, Androgen/genetics; Repressor Proteins; Skin Neoplasms/genetics; Sweat Gland Neoplasms/diagnosis; Sweat Gland Neoplasms/genetics; Sweat Glands/pathology; Transcription Factors/genetics; Tumor Suppressor Proteins; beta Catenin/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Skin Neoplasms / Sweat Gland Neoplasms / Carcinoma, Skin Appendage / Merkel cell polyomavirus / Insulinoma Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Am Acad Dermatol Year: 2022 Type: Article Affiliation country: Canada

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