Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.

Jagt, Jasmijn Z; Pothof, Christine D; Buiter, Hans J C; van Limbergen, Johan E; van Wijk, Michiel P; Benninga, Marc A; de Boer, Nanne K H; de Meij, Tim G J

Jagt, Jasmijn Z; Pothof, Christine D; Buiter, Hans J C; van Limbergen, Johan E; van Wijk, Michiel P; Benninga, Marc A; de Boer, Nanne K H; de Meij, Tim G J.

Affiliation

Jagt JZ; Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam, UMC, Vrije Universiteit Amsterdam, 1105 AZ, Amsterdam, The Netherlands. j.jagt1@amsterdamumc.nl.
Pothof CD; Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam, UMC, Vrije Universiteit Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
Buiter HJC; Department of Clinical Pharmacology and Pharmacy, Amsterdam, UMC, Vrije Universiteit Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
van Limbergen JE; Department of Pediatric Gastroenterology, UMC, Emma Children's Hospital, Amsterdam, Academic Medical Centre, 1081 HV, Amsterdam, The Netherlands.
van Wijk MP; Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam, UMC, Vrije Universiteit Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
Benninga MA; Department of Pediatric Gastroenterology, UMC, Emma Children's Hospital, Amsterdam, Academic Medical Centre, 1081 HV, Amsterdam, The Netherlands.
de Boer NKH; Department of Pediatric Gastroenterology, UMC, Emma Children's Hospital, Amsterdam, Academic Medical Centre, 1081 HV, Amsterdam, The Netherlands.
de Meij TGJ; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam, UMC, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands.

Dig Dis Sci ; 67(1): 241-251, 2022 01.

Article in En | MEDLINE | ID: mdl-33532972

Subject(s)

Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug-Related Side Effects and Adverse Reactions; Mercaptopurine/analogs & derivatives; Withholding Treatment/statistics & numerical data; Adolescent; Antimetabolites/administration & dosage; Antimetabolites/adverse effects; Antimetabolites/pharmacokinetics; Azathioprine/administration & dosage; Azathioprine/adverse effects; Azathioprine/pharmacokinetics; Biomarkers, Pharmacological/blood; Child; Cohort Studies; Colitis, Ulcerative/drug therapy; Colitis, Ulcerative/epidemiology; Colitis, Ulcerative/metabolism; Colitis, Ulcerative/pathology; Crohn Disease/drug therapy; Crohn Disease/epidemiology; Crohn Disease/metabolism; Crohn Disease/pathology; Drug Substitution/methods; Drug Substitution/statistics & numerical data; Drug-Related Side Effects and Adverse Reactions/blood; Drug-Related Side Effects and Adverse Reactions/diagnosis; Drug-Related Side Effects and Adverse Reactions/epidemiology; Drug-Related Side Effects and Adverse Reactions/etiology; Female; Guanine Nucleotides/blood; Humans; Male; Mercaptopurine/administration & dosage; Mercaptopurine/adverse effects; Mercaptopurine/pharmacokinetics; Netherlands/epidemiology; Retrospective Studies; Thionucleotides/blood

Key words

Adverse events; Inflammatory bowel disease; Metabolites; Pediatrics; Thiopurines

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azathioprine / Colitis, Ulcerative / Crohn Disease / Withholding Treatment / Drug-Related Side Effects and Adverse Reactions / Mercaptopurine Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Country/Region as subject: Europa Language: En Journal: Dig Dis Sci Year: 2022 Type: Article Affiliation country: Netherlands

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