Diarylheptanoid-chalcone hybrids with PTP1B and &#945;-glucosidase dual inhibition from Alpinia katsumadai.

He, Xiao-Feng; Chen, Ji-Jun; Li, Tian-Ze; Hu, Jing; Zhang, Xue-Mei; Geng, Chang-An

Diarylheptanoid-chalcone hybrids with PTP1B and α-glucosidase dual inhibition from Alpinia katsumadai.

He, Xiao-Feng; Chen, Ji-Jun; Li, Tian-Ze; Hu, Jing; Zhang, Xue-Mei; Geng, Chang-An.

Affiliation

He XF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Chen JJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Re
Li TZ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Hu J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Zhang XM; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Geng CA; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China. Electronic address: gengchangan@mail.kib.ac.cn.

Bioorg Chem ; 108: 104683, 2021 03.

Article in En | MEDLINE | ID: mdl-33545534

Subject(s)

Alpinia/enzymology; Chalcones/pharmacology; Diarylheptanoids/pharmacology; Enzyme Inhibitors/pharmacology; Glycoside Hydrolase Inhibitors/pharmacology; Hypoglycemic Agents/pharmacology; Animals; Chalcones/chemistry; Chalcones/isolation & purification; Diabetes Mellitus, Type 2/drug therapy; Diabetes Mellitus, Type 2/metabolism; Diarylheptanoids/chemistry; Diarylheptanoids/isolation & purification; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/isolation & purification; Glycoside Hydrolase Inhibitors/chemistry; Glycoside Hydrolase Inhibitors/isolation & purification; Hypoglycemic Agents/chemistry; Hypoglycemic Agents/isolation & purification; Mice; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism; Structure-Activity Relationship; alpha-Glucosidases/metabolism

Key words

Alpinia katsumadai; Antidiabetic effects; Katsumadainols A(1)−A(16); PTP1B/TCPTP selective inhibitors; α-glucosidase inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpinia / Diarylheptanoids / Chalcones / Enzyme Inhibitors / Glycoside Hydrolase Inhibitors / Hypoglycemic Agents Limits: Animals Language: En Journal: Bioorg Chem Year: 2021 Type: Article

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