Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.

Yeom, Eunbyul; Shin, Hyemi; Yoo, Wonbeak; Jun, Eunsung; Kim, Seokho; Hong, Seung Hyun; Kwon, Dae-Woo; Ryu, Tae Hoon; Suh, Jae Myoung; Kim, Song Cheol; Lee, Kyu-Sun; Yu, Kweon

Yeom, Eunbyul; Shin, Hyemi; Yoo, Wonbeak; Jun, Eunsung; Kim, Seokho; Hong, Seung Hyun; Kwon, Dae-Woo; Ryu, Tae Hoon; Suh, Jae Myoung; Kim, Song Cheol; Lee, Kyu-Sun; Yu, Kweon.

Affiliation

Yeom E; Metabolism and Neurophysiology Research Group, Disease Target Structure Research Center, KRIBB, Daejeon, Korea.
Shin H; Tunneling Nanotube Research Center, Korea University, Seoul, Korea.
Yoo W; Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Jun E; Environmental Disease Research Center, KRIBB, Daejeon, Korea.
Kim S; Department of Convergence Medicine and Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Institute for Life Sciences, AMIST, Asan Medical Center, Seoul, Korea.
Hong SH; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan, Korea.
Kwon DW; Metabolism and Neurophysiology Research Group, Disease Target Structure Research Center, KRIBB, Daejeon, Korea.
Ryu TH; Metabolism and Neurophysiology Research Group, Disease Target Structure Research Center, KRIBB, Daejeon, Korea.
Suh JM; Department of Functional Genomics, UST, Daejeon, Korea.
Kim SC; Metabolism and Neurophysiology Research Group, Disease Target Structure Research Center, KRIBB, Daejeon, Korea.
Lee KS; Department of Functional Genomics, UST, Daejeon, Korea.
Yu K; Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea. jmsuh@kaist.ac.kr.

Nat Cell Biol ; 23(2): 172-183, 2021 02.

Article in En | MEDLINE | ID: mdl-33558728

Subject(s)

Anorexia/metabolism; Brain/metabolism; Drosophila Proteins/metabolism; Intercellular Signaling Peptides and Proteins/metabolism; Neoplasms/metabolism; Neuropeptides/metabolism; Receptors, G-Protein-Coupled/metabolism; Amino Acid Sequence; Animals; Anorexia/etiology; Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/metabolism; Cell Line, Tumor; Disease Models, Animal; Drosophila Proteins/chemistry; Drosophila Proteins/genetics; Drosophila melanogaster/metabolism; Eye Neoplasms/pathology; Feeding Behavior; Humans; Hypothalamus/metabolism; Insulin/blood; Insulin/chemistry; Insulin/metabolism; Intercellular Signaling Peptides and Proteins/chemistry; Intercellular Signaling Peptides and Proteins/genetics; Mice, Inbred C57BL; Neoplasms/complications; Neurons/metabolism; Pancreatic Neoplasms/blood; Pancreatic Neoplasms/complications; Proteins/chemistry; Proteins/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptides / Brain / Anorexia / Drosophila Proteins / Intercellular Signaling Peptides and Proteins / Receptors, G-Protein-Coupled / Neoplasms Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2021 Type: Article

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