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The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider, Michael; Eichner, Ruth; Stroh, Jacob; Morath, Volker; Kuisl, Anna; Zecha, Jana; Lawatscheck, Jannis; Baek, Kheewoong; Garz, Anne-Kathrin; Rudelius, Martina; Deuschle, Friedrich-Christian; Keller, Ulrich; Lemeer, Simone; Verbeek, Mareike; Götze, Katharina S; Skerra, Arne; Weber, Wolfgang A; Buchner, Johannes; Schulman, Brenda A; Kuster, Bernhard; Fernández-Sáiz, Vanesa; Bassermann, Florian.
Affiliation
  • Heider M; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany.
  • Eichner R; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany.
  • Stroh J; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany.
  • Morath V; Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
  • Kuisl A; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany.
  • Zecha J; Department of Proteomics and Bioanalytics, Technical University of Munich, 85354 Freising, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Lawatscheck J; Center for Integrated Protein Science at the Department of Chemistry, Technical University of Munich, 85748 Garching, Germany.
  • Baek K; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Garz AK; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
  • Rudelius M; Institute of Pathology, Ludwig-Maximilians University, 80337 Munich, Germany.
  • Deuschle FC; Lehrstuhl für Biologische Chemie, Technical University of Munich, 85354 Freising, Germany.
  • Keller U; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Department of Hematology, Oncology and Tumor Immunology (Campus Benjamin Franklin), Charité - Universitätsmedizin Berlin, 12200 Berlin, Germany.
  • Lemeer S; Department of Proteomics and Bioanalytics, Technical University of Munich, 85354 Freising, Germany.
  • Verbeek M; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
  • Götze KS; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Skerra A; Lehrstuhl für Biologische Chemie, Technical University of Munich, 85354 Freising, Germany.
  • Weber WA; Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Buchner J; Center for Integrated Protein Science at the Department of Chemistry, Technical University of Munich, 85748 Garching, Germany.
  • Schulman BA; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
  • Kuster B; Department of Proteomics and Bioanalytics, Technical University of Munich, 85354 Freising, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Fernández-Sáiz V; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany. Electronic address: vanesa.fernandez@tum.de.
  • Bassermann F; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 He
Mol Cell ; 81(6): 1170-1186.e10, 2021 03 18.
Article in En | MEDLINE | ID: mdl-33571422
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Molecular Chaperones / HSP90 Heat-Shock Proteins / Fusion Regulatory Protein 1, Heavy Chain / Large Neutral Amino Acid-Transporter 1 / Ubiquitin-Protein Ligases / Adaptor Proteins, Signal Transducing / Immunologic Factors / Multiple Myeloma / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Molecular Chaperones / HSP90 Heat-Shock Proteins / Fusion Regulatory Protein 1, Heavy Chain / Large Neutral Amino Acid-Transporter 1 / Ubiquitin-Protein Ligases / Adaptor Proteins, Signal Transducing / Immunologic Factors / Multiple Myeloma / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: Germany