A dysregulated interleukin-18-interferon-Î³-CXCL9 axis impacts treatment response to canakinumab in systemic juvenile idiopathic arthritis.

Hinze, Tanja; Kessel, Christoph; Hinze, Claas H; Seibert, Julia; Gram, Hermann; Foell, Dirk

Hinze, Tanja; Kessel, Christoph; Hinze, Claas H; Seibert, Julia; Gram, Hermann; Foell, Dirk.

Affiliation

Hinze T; Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.
Kessel C; Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.
Hinze CH; Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.
Seibert J; Novartis Pharma AG, Basel, Switzerland.
Gram H; Novartis Pharma AG, Basel, Switzerland.
Foell D; Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany.

Rheumatology (Oxford) ; 60(11): 5165-5174, 2021 11 03.

Article in En | MEDLINE | ID: mdl-33576397

Subject(s)

Antibodies, Monoclonal, Humanized/therapeutic use; Arthritis, Juvenile/drug therapy; Chemokine CXCL9/blood; Interferon-gamma/blood; Interleukin-18/blood; Adolescent; Arthritis, Juvenile/blood; Biomarkers/blood; Child; Child, Preschool; Cohort Studies; Female; Humans; Male

Key words

CXCL9; canakinumab; interferon-gamma; interleukin-18; systemic juvenile idiopathic arthritis

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Juvenile / Interferon-gamma / Interleukin-18 / Chemokine CXCL9 / Antibodies, Monoclonal, Humanized Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2021 Type: Article Affiliation country: Germany

Fulltext

XML

PubMed Links

Search on Google