SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure.

Shen, Chih-Hao; Lin, Jr-Yu; Lu, Cheng-Yo; Yang, Sung-Sen; Peng, Chung-Kan; Huang, Kun-Lun

Shen, Chih-Hao; Lin, Jr-Yu; Lu, Cheng-Yo; Yang, Sung-Sen; Peng, Chung-Kan; Huang, Kun-Lun.

Affiliation

Shen CH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Gong Rd, Neihu 114, Taipei, Taiwan.
Lin JY; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
Lu CY; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
Yang SS; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
Peng CK; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Huang KL; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Gong Rd, Neihu 114, Taipei, Taiwan.

BMC Pulm Med ; 21(1): 58, 2021 Feb 15.

Article in En | MEDLINE | ID: mdl-33588817

Subject(s)

Acute Lung Injury/metabolism; Alveolar Epithelial Cells/metabolism; Claudins/genetics; Hyperoxia/metabolism; Protein Serine-Threonine Kinases/genetics; Pulmonary Alveoli/metabolism; Tight Junctions/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Acute Lung Injury/pathology; Alveolar Epithelial Cells/ultrastructure; Animals; Bronchoalveolar Lavage Fluid/chemistry; Claudins/metabolism; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Techniques; Hyperoxia/pathology; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Electron, Transmission; Permeability; Protein Serine-Threonine Kinases/metabolism; Pulmonary Alveoli/ultrastructure; Reactive Oxygen Species/metabolism; Signal Transduction; Tight Junctions/ultrastructure

Key words

Alveolar epithelium; Claudin-18; Hyperoxia; STE20/SPS1-related proline/alanine-rich kinase; p38 MAPK

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Alveoli / Protein Serine-Threonine Kinases / Hyperoxia / Tight Junctions / P38 Mitogen-Activated Protein Kinases / Acute Lung Injury / Alveolar Epithelial Cells / Claudins Limits: Animals Language: En Journal: BMC Pulm Med Year: 2021 Type: Article Affiliation country: Taiwan

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