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Massively parallel assessment of human variants with base editor screens.
Hanna, Ruth E; Hegde, Mudra; Fagre, Christian R; DeWeirdt, Peter C; Sangree, Annabel K; Szegletes, Zsofia; Griffith, Audrey; Feeley, Marissa N; Sanson, Kendall R; Baidi, Yossef; Koblan, Luke W; Liu, David R; Neal, James T; Doench, John G.
Affiliation
  • Hanna RE; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Hegde M; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Fagre CR; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • DeWeirdt PC; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Sangree AK; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Szegletes Z; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Griffith A; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Feeley MN; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Sanson KR; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA.
  • Baidi Y; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • Koblan LW; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
  • Neal JT; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • Doench JG; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA. Electronic address: jdoench@broadinstitute.org.
Cell ; 184(4): 1064-1080.e20, 2021 02 18.
Article in En | MEDLINE | ID: mdl-33606977
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / High-Throughput Nucleotide Sequencing / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / High-Throughput Nucleotide Sequencing / Gene Editing Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: United States