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TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau.
Ash, Peter E A; Lei, Shuwen; Shattuck, Jenifer; Boudeau, Samantha; Carlomagno, Yari; Medalla, Maria; Mashimo, Bryce L; Socorro, Guillermo; Al-Mohanna, Louloua F A; Jiang, Lulu; Öztürk, Muhammet M; Knobel, Mark; Ivanov, Pavel; Petrucelli, Leonard; Wegmann, Susanne; Kanaan, Nicholas M; Wolozin, Benjamin.
Affiliation
  • Ash PEA; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Lei S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Shattuck J; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Boudeau S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Carlomagno Y; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224.
  • Medalla M; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118.
  • Mashimo BL; Department of Neurology, Boston University School of Medicine, Boston, MA 02118.
  • Socorro G; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Al-Mohanna LFA; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Jiang L; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Öztürk MM; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Knobel M; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Ivanov P; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118.
  • Petrucelli L; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Wegmann S; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224.
  • Kanaan NM; German Center for Neurodegenerative Diseases, DZNE, Berlin, 10117, Germany.
  • Wolozin B; Department of Translational Neuroscience, Grand Rapids Research Center, Michigan State University, Grand Rapids, MI 49503.
Proc Natl Acad Sci U S A ; 118(9)2021 03 02.
Article in En | MEDLINE | ID: mdl-33619090
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Protein Multimerization / Protein Aggregation, Pathological / Protein Aggregates / T-Cell Intracellular Antigen-1 Type of study: Etiology_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Protein Multimerization / Protein Aggregation, Pathological / Protein Aggregates / T-Cell Intracellular Antigen-1 Type of study: Etiology_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article