Activated ALK Cooperates with N-Myc via Wnt/ß-Catenin Signaling to Induce Neuroendocrine Prostate Cancer.

Unno, Kenji; Chalmers, Zachary R; Pamarthy, Sahithi; Vatapalli, Rajita; Rodriguez, Yara; Lysy, Barbara; Mok, Hanlin; Sagar, Vinay; Han, Huiying; Yoo, Young A; Ku, Sheng-Yu; Beltran, Himisha; Zhao, Yue; Abdulkadir, Sarki A

Unno, Kenji; Chalmers, Zachary R; Pamarthy, Sahithi; Vatapalli, Rajita; Rodriguez, Yara; Lysy, Barbara; Mok, Hanlin; Sagar, Vinay; Han, Huiying; Yoo, Young A; Ku, Sheng-Yu; Beltran, Himisha; Zhao, Yue; Abdulkadir, Sarki A.

Affiliation

Unno K; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Chalmers ZR; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Pamarthy S; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Vatapalli R; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Rodriguez Y; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Lysy B; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Mok H; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Sagar V; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Han H; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Yoo YA; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Ku SY; Division of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Beltran H; Division of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Zhao Y; Department of Pathology, College of Basic Medical Science and First Affiliated Hospital, China Medical University, Shenyang, Liaoning, P.R. China.
Abdulkadir SA; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois. sarki.abdulkadir@northwestern.edu.

Cancer Res ; 81(8): 2157-2170, 2021 04 15.

Article in En | MEDLINE | ID: mdl-33637566

Subject(s)

Anaplastic Lymphoma Kinase/metabolism; Carcinoma, Neuroendocrine/etiology; N-Myc Proto-Oncogene Protein/metabolism; Prostatic Neoplasms/etiology; Wnt Signaling Pathway; Anaplastic Lymphoma Kinase/antagonists & inhibitors; Anaplastic Lymphoma Kinase/genetics; Animals; Carbazoles/therapeutic use; Carcinoma, Neuroendocrine/drug therapy; Carcinoma, Neuroendocrine/metabolism; Carcinoma, Neuroendocrine/pathology; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Humans; Male; Mice; Mutation; N-Myc Proto-Oncogene Protein/genetics; Neoplastic Stem Cells; Neuroblastoma/drug therapy; Neuroblastoma/etiology; Neuroblastoma/pathology; Piperidines/therapeutic use; Prostatic Neoplasms/drug therapy; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Protein Kinase Inhibitors/therapeutic use; Exome Sequencing; Wnt Signaling Pathway/drug effects; Wnt Signaling Pathway/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Carcinoma, Neuroendocrine / Wnt Signaling Pathway / N-Myc Proto-Oncogene Protein / Anaplastic Lymphoma Kinase Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cancer Res Year: 2021 Type: Article

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