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Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments.
Lee, Jun Young; Shin, Young Sup; Jeon, Sangeun; Lee, Se In; Noh, Soojin; Cho, Jung-Eun; Jang, Min Seong; Kim, Seungtaek; Song, Jong Hwan; Kim, Hyoung Rae; Park, Chul Min.
Affiliation
  • Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Jeon S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
  • Lee SI; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Noh S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Cho JE; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Jang MS; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
  • Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
  • Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
  • Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea; Korea University of Science and Technology, Daejeon 34114, South Korea. Electronic address: parkcm@krict.re.kr.
Bioorg Med Chem Lett ; 39: 127885, 2021 05 01.
Article in En | MEDLINE | ID: mdl-33662537
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Drug Design / Quinazolinones / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article Affiliation country: South Korea
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Drug Design / Quinazolinones / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article Affiliation country: South Korea