Hyperactivation of cyclin A-CDK induces centrosome overduplication and chromosome tetraploidization in mouse cells.

Niwa, Tetsuo; Akaike, Yasunori; Watanabe, Kaichi; Chibazakura, Taku

Niwa, Tetsuo; Akaike, Yasunori; Watanabe, Kaichi; Chibazakura, Taku.

Affiliation

Niwa T; Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.
Akaike Y; Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.
Watanabe K; Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.
Chibazakura T; Department of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan. Electronic address: taku@nodai.ac.jp.

Biochem Biophys Res Commun ; 549: 91-97, 2021 04 16.

Article in En | MEDLINE | ID: mdl-33667714

Subject(s)

Centrosome/metabolism; Chromosomes, Mammalian/metabolism; Cyclin A/metabolism; Cyclin-Dependent Kinases/metabolism; Polyploidy; Animals; Cell Cycle Proteins/metabolism; Cyclin A/genetics; Embryo, Mammalian/cytology; Fibroblasts/metabolism; Humans; Mice; Mitosis; Mutation/genetics; S Phase

Key words

CDK inhibitors; Centrosome; Cyclin A; Cyclin degradation; Tetraploidization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyploidy / Cyclin-Dependent Kinases / Centrosome / Cyclin A / Chromosomes, Mammalian Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2021 Type: Article Affiliation country: Japan

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